Abstract: The dry-hot river valley was a special ecosystem with fragile ecological environment and relatively short water resources, so the exploitation and utilization of water resources was an urgent problem to be solved. In order to clarify the strategy of comprehensive development and utilization of water resources in the dry-hot valley of Jinsha River in Yunnan province, this paper makes an in-depth study on comprehensive development and utilization of water resources in the dry-hot valley of Jinsha River in Yunnan Province. Based on field investigation, data analysis and literature review, the present situation, problems and development potential of water resources in this region were discussed, and a series of strategies and suggestions were put forward for the comprehensive development and utilization of water resources for the sustainable development of water, light, heat, soil, agriculture and forest, aiming at improving the sustainable utilization of water resources and guaranteeing regional economic development and ecological environment protection..